In the present study, spherical microbeads are able to prolong and control the release of nifedipin. were prepared by ionotropic gelation method, using sodium alginate as the hydrophilic carrier in combination with HPMC and sodium alginate as drug release modifiers in various proportions to overcome the drug related adverse effects, improve drug bioavailability in different GI tract conditions. Formulated microbeads were investigated for physicochemical properties and drug release potential. All investigated properties showed satisfactory results. While testing size distribution, flow properties and mean diameter of microbeads, there was no significant drug-polymer interactions were observed. The formulated floating alginate beads have shown higher percentage (28.11 % to 39.98 %) of drug loading, particle size (610.75 to 845.62 , higher release of drug. The Optical microscopy of floating alginate beads reveals that the beads are mainly spherical and the use of calcium carbonate, which provides floating property. In-vitro dissolution study showed that 90 % drug release, amongst the formulations, formulation 4 released Nifedipin for prolonged duration (12 hours). Formulated floating beads of Nifedipin showed good swelling behavior.
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